KALRN
Entrez ID: 8997
Full name: kalirin RhoGEF kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: Trio
Chromosomal location: 3q21.1-q21.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
KALRN
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity....
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
View more >>
GO - Biological processes (BP):
adult locomotory behavior, ephrin receptor signaling pathway, G protein-coupled receptor signaling pathway, habituation, intracellular signal transduction, lactation, maternal behavior, maternal process involved in parturition, memory, negative regulation of growth hormone secretion, nervous system ...
adult locomotory behavior, ephrin receptor signaling pathway, G protein-coupled receptor signaling pathway, habituation, intracellular signal transduction, lactation, maternal behavior, maternal process involved in parturition, memory, negative regulation of growth hormone secretion, nervous system development, neuromuscular junction development, positive regulation of apoptotic process, positive regulation of dendritic spine morphogenesis, positive regulation of GTPase activity, protein phosphorylation, regulation of Rho protein signal transduction, regulation of small GTPase mediated signal transduction, signal transduction, social behavior, vesicle-mediated transport
View more >>
GO - Molecular function (MF):
ATP binding, guanyl-nucleotide exchange factor activity, metal ion binding, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity...
ATP binding, guanyl-nucleotide exchange factor activity, metal ion binding, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity
View more >>
GO - Cellular component (CC):
actin cytoskeleton, cytosol, extracellular exosome, nucleoplasm...
actin cytoskeleton, cytosol, extracellular exosome, nucleoplasm
View more >>
kalirin RhoGEF kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for KALRN in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc