BUB1B
Entrez ID: 701
Full name: BUB1 mitotic checkpoint serine/threonine kinase B
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: BUB
Chromosomal location: 15q15.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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BUB1B
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (A...
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
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GO - Biological processes (BP):
anaphase-promoting complex-dependent catabolic process, apoptotic process, cell division, meiotic sister chromatid cohesion, centromeric, mitotic cell cycle, mitotic cell cycle checkpoint, mitotic spindle assembly checkpoint, regulation of mitotic cell cycle phase transition, ubiquitin-dependent pro...
anaphase-promoting complex-dependent catabolic process, apoptotic process, cell division, meiotic sister chromatid cohesion, centromeric, mitotic cell cycle, mitotic cell cycle checkpoint, mitotic spindle assembly checkpoint, regulation of mitotic cell cycle phase transition, ubiquitin-dependent protein catabolic process
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
microtubule organizing center, spindle, cytosol, anaphase-promoting complex, condensed nuclear chromosome kinetochore, condensed chromosome kinetochore, condensed chromosome outer kinetochore, cytoplasm, kinetochore, perinuclear region of cytoplasm...
microtubule organizing center, spindle, cytosol, anaphase-promoting complex, condensed nuclear chromosome kinetochore, condensed chromosome kinetochore, condensed chromosome outer kinetochore, cytoplasm, kinetochore, perinuclear region of cytoplasm
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BUB1 mitotic checkpoint serine/threonine kinase B
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Gatekeeper
A-loop
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αC-helix
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A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for BUB1B in
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*NOTE: the Kaplan plots were collected from OncoLnc