BRD4
Entrez ID: 23476
Full name: bromodomain containing 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: BRD
Chromosomal location: 19p13.12
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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BRD4
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmi...
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504).
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GO - Biological processes (BP):
cellular response to DNA damage stimulus, chromatin organization, chromatin remodeling, negative regulation of DNA damage checkpoint, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of histone H3-K36 trimethylation, positive regulation of I-kappaB kinase/NF-kappaB s...
cellular response to DNA damage stimulus, chromatin organization, chromatin remodeling, negative regulation of DNA damage checkpoint, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of histone H3-K36 trimethylation, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation from RNA polymerase II promoter, regulation of inflammatory response, regulation of phosphorylation of RNA polymerase II C-terminal domain, regulation of transcription involved in G1/S transition of mitotic cell cycle, viral process
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GO - Molecular function (MF):
chromatin binding, enzyme binding, lysine-acetylated histone binding, p53 binding, P-TEFb complex binding, RNA polymerase II CTD heptapeptide repeat kinase activity, RNA polymerase II C-terminal domain binding, transcription regulator recruiting activity...
chromatin binding, enzyme binding, lysine-acetylated histone binding, p53 binding, P-TEFb complex binding, RNA polymerase II CTD heptapeptide repeat kinase activity, RNA polymerase II C-terminal domain binding, transcription regulator recruiting activity
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GO - Cellular component (CC):
condensed nuclear chromosome, nucleoplasm, nucleus, chromosome...
condensed nuclear chromosome, nucleoplasm, nucleus, chromosome
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bromodomain containing 4
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Kaplan plot for BRD4 in
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*NOTE: the Kaplan plots were collected from OncoLnc