FAM20B
Entrez ID: 9917
Full name: FAM20B glycosaminoglycan xylosylkinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PKL: FJ
Chromosomal location: 1q25.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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FAM20B
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-pr...
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.
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GO - Biological processes (BP):
phosphorylation, proteoglycan biosynthetic process...
phosphorylation, proteoglycan biosynthetic process
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GO - Molecular function (MF):
ATP binding, kinase activity, metal ion binding, phosphotransferase activity, alcohol group as acceptor...
ATP binding, kinase activity, metal ion binding, phosphotransferase activity, alcohol group as acceptor
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GO - Cellular component (CC):
Golgi apparatus, Golgi membrane, nucleoplasm, integral component of membrane...
Golgi apparatus, Golgi membrane, nucleoplasm, integral component of membrane
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FAM20B glycosaminoglycan xylosylkinase
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 10 samples
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*NOTE: the Kaplan plots were collected from OncoLnc