ULK1
Entrez ID: 8408
Full name: unc-51 like autophagy activating kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: ULK: ULK
Chromosomal location: 12q24.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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ULK1
Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157,...
Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726).
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GO - Biological processes (BP):
autophagosome assembly, autophagy, axon extension, cellular response to nutrient levels, macroautophagy, negative regulation of protein-containing complex assembly, neuron projection development, neuron projection regeneration, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, pos...
autophagosome assembly, autophagy, axon extension, cellular response to nutrient levels, macroautophagy, negative regulation of protein-containing complex assembly, neuron projection development, neuron projection regeneration, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation by symbiont of host autophagy, positive regulation of autophagosome assembly, positive regulation of autophagy, protein autophosphorylation, protein localization, protein phosphorylation, regulation of autophagy, regulation of macroautophagy, response to starvation, signal transduction
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GO - Molecular function (MF):
ATP binding, GTPase binding, identical protein binding, kinase activity, protein-containing complex binding, protein serine/threonine kinase activity, Rab GTPase binding...
ATP binding, GTPase binding, identical protein binding, kinase activity, protein-containing complex binding, protein serine/threonine kinase activity, Rab GTPase binding
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GO - Cellular component (CC):
cytosol, endoplasmic reticulum membrane, recycling endosome, mitochondrial outer membrane, Atg1/ULK1 kinase complex, autophagosome, axon, cytoplasm, extrinsic component of autophagosome membrane, extrinsic component of omegasome membrane, extrinsic component of phagophore assembly site membrane, mem...
cytosol, endoplasmic reticulum membrane, recycling endosome, mitochondrial outer membrane, Atg1/ULK1 kinase complex, autophagosome, axon, cytoplasm, extrinsic component of autophagosome membrane, extrinsic component of omegasome membrane, extrinsic component of phagophore assembly site membrane, membrane, phagophore assembly site, phagophore assembly site membrane
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unc-51 like autophagy activating kinase 1
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for ULK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc