RPS6KA4
Entrez ID: 8986
Full name: ribosomal protein S6 kinase A4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: RSK: MSK
Chromosomal location: 11q13.1
Substructure location: Gatekeeper: 115 A-loop: 178...188, 191...202 G-loop: [N/A] αC-helix: [N/A]
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RPS6KA4
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation o...
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
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GO - Biological processes (BP):
histone H3-S10 phosphorylation, histone H3-S28 phosphorylation, histone phosphorylation, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, negative regulation of cytokine production, positive regulation of CREB transcription factor activity, positive...
histone H3-S10 phosphorylation, histone H3-S28 phosphorylation, histone phosphorylation, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, negative regulation of cytokine production, positive regulation of CREB transcription factor activity, positive regulation of histone acetylation, positive regulation of histone phosphorylation, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription by RNA polymerase II, protein phosphorylation, regulation of transcription, DNA-templated
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity...
ATP binding, magnesium ion binding, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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ribosomal protein S6 kinase A4
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Kaplan plot for RPS6KA4 in
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*NOTE: the Kaplan plots were collected from OncoLnc