STK16
Entrez ID: 8576
Full name: serine/threonine kinase 16
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NAK: MPSK
Chromosomal location: 2q35
Substructure location: Gatekeeper: 98 A-loop: 165...191, 193...197 G-loop: [N/A] αC-helix: 56...70
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STK16
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interac...
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
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GO - Biological processes (BP):
cellular response to transforming growth factor beta stimulus, positive regulation of transcription by RNA polymerase II, protein autophosphorylation...
cellular response to transforming growth factor beta stimulus, positive regulation of transcription by RNA polymerase II, protein autophosphorylation
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine kinase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine kinase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding
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GO - Cellular component (CC):
cytosol, cytoplasm, Golgi-associated vesicle, membrane, perinuclear region of cytoplasm...
cytosol, cytoplasm, Golgi-associated vesicle, membrane, perinuclear region of cytoplasm
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serine/threonine kinase 16
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*NOTE: the Kaplan plots were collected from OncoLnc