PAK3
Entrez ID: 5063
Full name: p21 (RAC1) activated kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: PAKA
Chromosomal location: Xq23
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PAK3
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the sma...
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.
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GO - Biological processes (BP):
activation of protein kinase activity, axonogenesis, cellular response to organic cyclic compound, dendrite development, dendritic spine morphogenesis, ephrin receptor signaling pathway, positive regulation of dendritic spine morphogenesis, positive regulation of DNA biosynthetic process, positive r...
activation of protein kinase activity, axonogenesis, cellular response to organic cyclic compound, dendrite development, dendritic spine morphogenesis, ephrin receptor signaling pathway, positive regulation of dendritic spine morphogenesis, positive regulation of DNA biosynthetic process, positive regulation of fibroblast migration, positive regulation of neuron apoptotic process, regulation of actin filament polymerization, regulation of axonogenesis, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stimulatory C-type lectin receptor signaling pathway, stress-activated protein kinase signaling cascade, synapse organization, T cell costimulation, T cell receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase activity, metal ion binding, protein serine/threonine kinase activity, Rho GTPase binding, SH3 domain binding...
ATP binding, MAP kinase kinase activity, metal ion binding, protein serine/threonine kinase activity, Rho GTPase binding, SH3 domain binding
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GO - Cellular component (CC):
cytosol, endosome, plasma membrane, cytoplasm, glutamatergic synapse, postsynaptic density...
cytosol, endosome, plasma membrane, cytoplasm, glutamatergic synapse, postsynaptic density
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p21 (RAC1) activated kinase 3
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A-loop
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αC-helix
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G-loop
αC-helix
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Kaplan plot for PAK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc