TRIO
Entrez ID: 7204
Full name: trio Rho guanine nucleotide exchange factor
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: Trio
Chromosomal location: 5p15.2
Substructure location: Gatekeeper: 2869 A-loop: 2935...2957 G-loop: [N/A] αC-helix: [N/A]
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TRIO
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). In developing hippocampal neurons, limits dendrite fo...
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).
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GO - Biological processes (BP):
axon guidance, central nervous system development, G protein-coupled receptor signaling pathway, negative regulation of fat cell differentiation, positive regulation of apoptotic process, regulation of small GTPase mediated signal transduction, transmembrane receptor protein tyrosine phosphatase sig...
axon guidance, central nervous system development, G protein-coupled receptor signaling pathway, negative regulation of fat cell differentiation, positive regulation of apoptotic process, regulation of small GTPase mediated signal transduction, transmembrane receptor protein tyrosine phosphatase signaling pathway
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GO - Molecular function (MF):
ATP binding, guanyl-nucleotide exchange factor activity, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity...
ATP binding, guanyl-nucleotide exchange factor activity, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity
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GO - Cellular component (CC):
cytosol, cell projection...
cytosol, cell projection
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trio Rho guanine nucleotide exchange factor
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*NOTE: the Kaplan plots were collected from OncoLnc