CDKL5
Entrez ID: 6792
Full name: cyclin dependent kinase like 5
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDKL
Chromosomal location: Xp22.13
Substructure location: Gatekeeper: 89 A-loop: 152...176 G-loop: [N/A] αC-helix: 55...66
Please click HERE
for better display.
CDKL5
Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175)....
Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175).
View more >>
GO - Biological processes (BP):
neuron migration, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of dendritic spine development, positive regulation of GTPase activity, protein autophosphorylation, protein phosphorylation, regulation of cilium assembly, regulation of dendr...
neuron migration, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of dendritic spine development, positive regulation of GTPase activity, protein autophosphorylation, protein phosphorylation, regulation of cilium assembly, regulation of dendrite development, regulation of postsynapse organization
View more >>
GO - Molecular function (MF):
ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, protein kinase activity, protein serine/threonine kinase activity, Rac GTPase binding...
ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, protein kinase activity, protein serine/threonine kinase activity, Rac GTPase binding
View more >>
GO - Cellular component (CC):
centrosome, ciliary basal body, nucleus, ruffle membrane, ciliary tip, dendrite cytoplasm, dendritic growth cone, glutamatergic synapse, perinuclear region of cytoplasm, postsynaptic density, intracellular component...
centrosome, ciliary basal body, nucleus, ruffle membrane, ciliary tip, dendrite cytoplasm, dendritic growth cone, glutamatergic synapse, perinuclear region of cytoplasm, postsynaptic density, intracellular component
View more >>
cyclin dependent kinase like 5
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for CDKL5 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc