STK10
Entrez ID: 6793
Full name: serine/threonine kinase 10
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: SLK
Chromosomal location: 5q35.1
Substructure location: Gatekeeper: 110 A-loop: 174...197 G-loop: [N/A] αC-helix: 75...87
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STK10
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle r...
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
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GO - Biological processes (BP):
activation of protein kinase activity, cell cycle, lymphocyte aggregation, neutrophil degranulation, protein autophosphorylation, protein phosphorylation, regulation of lymphocyte migration, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein ki...
activation of protein kinase activity, cell cycle, lymphocyte aggregation, neutrophil degranulation, protein autophosphorylation, protein phosphorylation, regulation of lymphocyte migration, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, identical protein binding, protein homodimerization activity, protein serine/threonine kinase activity...
ATP binding, identical protein binding, protein homodimerization activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
extracellular exosome, plasma membrane, cytoplasm, specific granule membrane...
extracellular exosome, plasma membrane, cytoplasm, specific granule membrane
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serine/threonine kinase 10
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*NOTE: the Kaplan plots were collected from OncoLnc