MAP4K4
Entrez ID: 9448
Full name: mitogen-activated protein kinase kinase kinase kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: MSN
Chromosomal location: 2q11.2
Substructure location: Gatekeeper: 105 A-loop: [N/A] G-loop: 31...37 αC-helix: 63...73
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MAP4K4
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322....
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
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GO - Biological processes (BP):
activation of protein kinase activity, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of cell-matrix adhesion, neuron projection morphogenesis, positive regulation of ARF protein signal transduction, positive regulation of cell migration, positive re...
activation of protein kinase activity, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of cell-matrix adhesion, neuron projection morphogenesis, positive regulation of ARF protein signal transduction, positive regulation of cell migration, positive regulation of focal adhesion assembly, positive regulation of focal adhesion disassembly, positive regulation of GTPase activity, positive regulation of keratinocyte migration, protein phosphorylation, regulation of JNK cascade, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, creatine kinase activity, microtubule binding, protein serine/threonine kinase activity...
ATP binding, creatine kinase activity, microtubule binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytoplasm, focal adhesion...
cytoplasm, focal adhesion
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mitogen-activated protein kinase kinase kinase kinase 4
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Kaplan plot for MAP4K4 in
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*NOTE: the Kaplan plots were collected from OncoLnc