PAK4
Entrez ID: 10298
Full name: p21 (RAC1) activated kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: PAKB
Chromosomal location: 19q13.2
Substructure location: Gatekeeper: 395 A-loop: 457...480 G-loop: 327...333 αC-helix: 354...356
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PAK4
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformati...
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
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GO - Biological processes (BP):
activation of protein kinase activity, apoptotic process, cell cycle, cell migration, cellular response to organic cyclic compound, cytoskeleton organization, dendritic spine development, negative regulation of endothelial cell apoptotic process, positive regulation of angiogenesis, regulation of ce...
activation of protein kinase activity, apoptotic process, cell cycle, cell migration, cellular response to organic cyclic compound, cytoskeleton organization, dendritic spine development, negative regulation of endothelial cell apoptotic process, positive regulation of angiogenesis, regulation of cell growth, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, cadherin binding involved in cell-cell adhesion, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, cadherin binding involved in cell-cell adhesion, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
Golgi apparatus, adherens junction, cytoplasm, focal adhesion...
Golgi apparatus, adherens junction, cytoplasm, focal adhesion
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p21 (RAC1) activated kinase 4
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Kaplan plot for PAK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc