EGFR
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, e...
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity).
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GO - Biological processes (BP):
activation of phospholipase A2 activity by calcium-mediated signaling, activation of phospholipase C activity, astrocyte activation, cell-cell adhesion, cell differentiation, cell surface receptor signaling pathway, cellular response to amino acid stimulus, cellular response to cadmium ion, cellular...
activation of phospholipase A2 activity by calcium-mediated signaling, activation of phospholipase C activity, astrocyte activation, cell-cell adhesion, cell differentiation, cell surface receptor signaling pathway, cellular response to amino acid stimulus, cellular response to cadmium ion, cellular response to dexamethasone stimulus, cellular response to epidermal growth factor stimulus, cellular response to estradiol stimulus, cellular response to mechanical stimulus, cellular response to reactive oxygen species, cerebral cortex cell migration, circadian rhythm, digestive tract morphogenesis, diterpenoid metabolic process, embryonic placenta development, epidermal growth factor receptor signaling pathway, ERBB2 signaling pathway, eyelid development in camera-type eye, hair follicle development, hydrogen peroxide metabolic process, learning or memory, liver regeneration, lung development, magnesium ion homeostasis, MAPK cascade, membrane organization, midgut development, morphogenesis of an epithelial fold, multicellular organism development, negative regulation of apoptotic process, negative regulation of cardiocyte differentiation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of ERBB signaling pathway, negative regulation of mitotic cell cycle, negative regulation of Notch signaling pathway, negative regulation of protein catabolic process, neuron projection morphogenesis, ossification, ovulation cycle, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of blood vessel diameter, positive regulation of bone resorption, positive regulation of canonical Wnt signaling pathway, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of epithelial cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of fibroblast proliferation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of inflammatory response, positive regulation of kinase activity, positive regulation of MAP kinase activity, positive regulation of NIK/NF-kappaB signaling, positive regulation of nitric oxide mediated signal transduction, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphorylation, positive regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of prolactin secretion, positive regulation of protein kinase B signaling, positive regulation of protein kinase C activity, positive regulation of protein localization to plasma membrane, positive regulation of protein phosphorylation, positive regulation of smooth muscle cell proliferation, positive regulation of superoxide anion generation, positive regulation of synaptic transmission, glutamatergic, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of vasoconstriction, protein autophosphorylation, protein insertion into membrane, regulation of cell motility, regulation of ERK1 and ERK2 cascade, regulation of JNK cascade, regulation of nitric-oxide synthase activity, regulation of peptidyl-tyrosine phosphorylation, regulation of phosphatidylinositol 3-kinase signaling, regulation of transcription by RNA polymerase II, response to calcium ion, response to cobalamin, response to hydroxyisoflavone, response to osmotic stress, response to UV-A, salivary gland morphogenesis, signal transduction, tongue development, translation, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing
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GO - Molecular function (MF):
actin filament binding, ATPase binding, ATP binding, cadherin binding, calmodulin binding, chromatin binding, double-stranded DNA binding, enzyme binding, epidermal growth factor-activated receptor activity, epidermal growth factor binding, identical protein binding, integrin binding, MAP kinase kin...
actin filament binding, ATPase binding, ATP binding, cadherin binding, calmodulin binding, chromatin binding, double-stranded DNA binding, enzyme binding, epidermal growth factor-activated receptor activity, epidermal growth factor binding, identical protein binding, integrin binding, MAP kinase kinase kinase activity, protein kinase binding, protein phosphatase binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity, ubiquitin protein ligase binding, virus receptor activity
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GO - Cellular component (CC):
endoplasmic reticulum membrane, early endosome membrane, endosome, endosome membrane, multivesicular body, internal vesicle lumen, extracellular space, Golgi membrane, nuclear membrane, nucleus, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, integral component of plasma ...
endoplasmic reticulum membrane, early endosome membrane, endosome, endosome membrane, multivesicular body, internal vesicle lumen, extracellular space, Golgi membrane, nuclear membrane, nucleus, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, integral component of plasma membrane, plasma membrane, Shc-EGFR complex, cell junction, cell surface, clathrin-coated vesicle membrane, cytoplasm, endocytic vesicle, focal adhesion, membrane, membrane raft, perinuclear region of cytoplasm, protein-containing complex, receptor complex, synapse
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