RAF1
Entrez ID: 5894
Full name: Raf-1 proto-oncogene, serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RAF: RAF
Chromosomal location: 3p25.2
Substructure location: Gatekeeper: 421 A-loop: 485...510 G-loop: [N/A] αC-helix: [N/A]
Please click HERE
for better display.
RAF1
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic tra...
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
View more >>
GO - Biological processes (BP):
activation of adenylate cyclase activity, activation of MAPKK activity, apoptotic process, cell differentiation, death-inducing signaling complex assembly, face development, heart development, insulin secretion involved in cellular response to glucose stimulus, intermediate filament cytoskeleton org...
activation of adenylate cyclase activity, activation of MAPKK activity, apoptotic process, cell differentiation, death-inducing signaling complex assembly, face development, heart development, insulin secretion involved in cellular response to glucose stimulus, intermediate filament cytoskeleton organization, ion transmembrane transport, MAPK cascade, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of protein-containing complex assembly, neurotrophin TRK receptor signaling pathway, platelet activation, positive regulation of peptidyl-serine phosphorylation, positive regulation of transcription by RNA polymerase II, protein phosphorylation, regulation of apoptotic process, regulation of cell differentiation, regulation of cell motility, regulation of Rho protein signal transduction, response to hypoxia, response to muscle stretch, signal transduction, somatic stem cell population maintenance, stimulatory C-type lectin receptor signaling pathway, thymus development, thyroid gland development, wound healing
View more >>
GO - Molecular function (MF):
adenylate cyclase activator activity, adenylate cyclase binding, ATP binding, enzyme binding, identical protein binding, MAP kinase kinase kinase activity, metal ion binding, mitogen-activated protein kinase kinase binding, protein-containing complex binding, protein kinase activity, protein serine/...
adenylate cyclase activator activity, adenylate cyclase binding, ATP binding, enzyme binding, identical protein binding, MAP kinase kinase kinase activity, metal ion binding, mitogen-activated protein kinase kinase binding, protein-containing complex binding, protein kinase activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
cytosol, Golgi apparatus, mitochondrial outer membrane, mitochondrion, nuclear speck, plasma membrane, cell, cytoplasm, pseudopodium...
cytosol, Golgi apparatus, mitochondrial outer membrane, mitochondrion, nuclear speck, plasma membrane, cell, cytoplasm, pseudopodium
View more >>
Raf-1 proto-oncogene, serine/threonine kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for RAF1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc