ERBB2
Entrez ID: 2064
Full name: erb-b2 receptor tyrosine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: EGFR
Chromosomal location: 17q12
Substructure location: Gatekeeper: 798 A-loop: 862...887 G-loop: 726...732 αC-helix: 761...774
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ERBB2
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulate...
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
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GO - Biological processes (BP):
cell surface receptor signaling pathway, cellular response to epidermal growth factor stimulus, cellular response to growth factor stimulus, enzyme linked receptor protein signaling pathway, ERBB2 signaling pathway, heart development, intracellular signal transduction, MAPK cascade, motor neuron axo...
cell surface receptor signaling pathway, cellular response to epidermal growth factor stimulus, cellular response to growth factor stimulus, enzyme linked receptor protein signaling pathway, ERBB2 signaling pathway, heart development, intracellular signal transduction, MAPK cascade, motor neuron axon guidance, multicellular organism development, myelination, negative regulation of ERBB signaling pathway, negative regulation of immature T cell proliferation in thymus, neuromuscular junction development, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, peripheral nervous system development, phosphatidylinositol 3-kinase signaling, positive regulation of cell adhesion, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of GTPase activity, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of MAP kinase activity, positive regulation of protein kinase B signaling, positive regulation of protein phosphorylation, positive regulation of protein targeting to membrane, positive regulation of transcription by RNA polymerase I, positive regulation of translation, protein autophosphorylation, protein phosphorylation, regulation of angiogenesis, regulation of cell motility, regulation of ERK1 and ERK2 cascade, regulation of microtubule-based process, regulation of transcription by RNA polymerase II, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing
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GO - Molecular function (MF):
ATP binding, ErbB-3 class receptor binding, identical protein binding, protein C-terminus binding, protein heterodimerization activity, protein phosphatase binding, protein tyrosine kinase activity, RNA polymerase I core binding, transmembrane receptor protein tyrosine kinase activity, transmembrane...
ATP binding, ErbB-3 class receptor binding, identical protein binding, protein C-terminus binding, protein heterodimerization activity, protein phosphatase binding, protein tyrosine kinase activity, RNA polymerase I core binding, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity
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GO - Cellular component (CC):
cytosol, early endosome, endosome membrane, nucleus, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, ERBB3:ERBB2 complex, integral component of plasma membrane, plasma membrane, integral component of membrane, myelin sheath, perinuclear region of cytoplasm, receptor compl...
cytosol, early endosome, endosome membrane, nucleus, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, ERBB3:ERBB2 complex, integral component of plasma membrane, plasma membrane, integral component of membrane, myelin sheath, perinuclear region of cytoplasm, receptor complex
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erb-b2 receptor tyrosine kinase 2
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Kaplan plot for ERBB2 in
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*NOTE: the Kaplan plots were collected from OncoLnc