NTRK1
Entrez ID: 4914
Full name: neurotrophic receptor tyrosine kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Trk
Chromosomal location: 1q23.1
Substructure location: Gatekeeper: 589 A-loop: 667...692 G-loop: 515...522 αC-helix: 552...566
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NTRK1
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubM...
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
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GO - Biological processes (BP):
activation of MAPKK activity, aging, axon guidance, axonogenesis involved in innervation, B cell differentiation, behavioral response to formalin induced pain, cellular response to nerve growth factor stimulus, cellular response to nicotine, circadian rhythm, detection of mechanical stimulus involve...
activation of MAPKK activity, aging, axon guidance, axonogenesis involved in innervation, B cell differentiation, behavioral response to formalin induced pain, cellular response to nerve growth factor stimulus, cellular response to nicotine, circadian rhythm, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, learning or memory, mechanoreceptor differentiation, multicellular organism development, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, nerve growth factor signaling pathway, nervous system development, neuron development, neuron projection development, neurotrophin TRK receptor signaling pathway, olfactory nerve development, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, phosphatidylinositol-mediated signaling, positive regulation of angiogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of GTPase activity, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of neuron projection development, positive regulation of NF-kappaB transcription factor activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of programmed cell death, positive regulation of protein phosphorylation, positive regulation of Ras protein signal transduction, positive regulation of synapse assembly, positive regulation of synaptic transmission, glutamatergic, programmed cell death involved in cell development, protein autophosphorylation, protein phosphorylation, regulation of MAPK cascade, regulation of protein kinase B signaling, response to axon injury, response to electrical stimulus, response to hydrostatic pressure, response to nutrient levels, response to radiation, Sertoli cell development, sympathetic nervous system development, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, GPI-linked ephrin receptor activity, identical protein binding, kinase binding, nerve growth factor binding, nerve growth factor receptor activity, neurotrophin binding, neurotrophin p75 receptor binding, neurotrophin receptor activity, protein homodimerization activity, protein tyrosin...
ATP binding, GPI-linked ephrin receptor activity, identical protein binding, kinase binding, nerve growth factor binding, nerve growth factor receptor activity, neurotrophin binding, neurotrophin p75 receptor binding, neurotrophin receptor activity, protein homodimerization activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
early endosome, early endosome membrane, endosome membrane, late endosome, late endosome membrane, recycling endosome membrane, Golgi membrane, integral component of plasma membrane, plasma membrane, axon, cell surface, dendrite, neuronal cell body, protein-containing complex, receptor complex...
early endosome, early endosome membrane, endosome membrane, late endosome, late endosome membrane, recycling endosome membrane, Golgi membrane, integral component of plasma membrane, plasma membrane, axon, cell surface, dendrite, neuronal cell body, protein-containing complex, receptor complex
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neurotrophic receptor tyrosine kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc