FES
Entrez ID: 2242
Full name: FES proto-oncogene, tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Fer
Chromosomal location: 15q26.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 568...575 αC-helix: 598...601
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FES
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts ...
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
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GO - Biological processes (BP):
cell adhesion, cell differentiation, cell migration, cellular response to vitamin D, centrosome cycle, chemotaxis, microtubule bundle formation, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of actin cytoskeleton reorganization, positive regulation of ...
cell adhesion, cell differentiation, cell migration, cellular response to vitamin D, centrosome cycle, chemotaxis, microtubule bundle formation, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of actin cytoskeleton reorganization, positive regulation of microtubule polymerization, positive regulation of monocyte differentiation, positive regulation of myeloid cell differentiation, positive regulation of neuron projection development, protein autophosphorylation, regulation of cell adhesion, regulation of cell differentiation, regulation of cell motility, regulation of cell population proliferation, regulation of cell shape, regulation of mast cell degranulation, regulation of vesicle-mediated transport, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, immunoglobulin receptor binding, microtubule binding, non-membrane spanning protein tyrosine kinase activity, phosphatidylinositol binding, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, immunoglobulin receptor binding, microtubule binding, non-membrane spanning protein tyrosine kinase activity, phosphatidylinositol binding, protein tyrosine kinase activity, signaling receptor binding
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GO - Cellular component (CC):
microtubule cytoskeleton, cytosol, Golgi apparatus, extrinsic component of cytoplasmic side of plasma membrane, cytoplasm, cytoplasmic vesicle, focal adhesion...
microtubule cytoskeleton, cytosol, Golgi apparatus, extrinsic component of cytoplasmic side of plasma membrane, cytoplasm, cytoplasmic vesicle, focal adhesion
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FES proto-oncogene, tyrosine kinase
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Kaplan plot for FES in
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*NOTE: the Kaplan plots were collected from OncoLnc