YES1
Entrez ID: 7525
Full name: YES proto-oncogene 1, Src family tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Src: SrcA
Chromosomal location: 18p11.32
Substructure location: Gatekeeper: 348 A-loop: 413...437 G-loop: [N/A] αC-helix: [N/A]
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YES1
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the ...
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
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GO - Biological processes (BP):
cell differentiation, cellular protein modification process, cellular response to platelet-derived growth factor stimulus, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, ephrin receptor signaling pathway, Fc-gamma receptor signaling pathway involve...
cell differentiation, cellular protein modification process, cellular response to platelet-derived growth factor stimulus, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, ephrin receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, leukocyte migration, peptidyl-tyrosine autophosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of transcription by RNA polymerase II, regulation of cell population proliferation, regulation of glucose transmembrane transport, regulation of vascular permeability, T cell costimulation, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, enzyme binding, epidermal growth factor receptor binding, ion channel binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, enzyme binding, epidermal growth factor receptor binding, ion channel binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity, signaling receptor binding
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GO - Cellular component (CC):
actin filament, microtubule organizing center, cytosol, extracellular exosome, Golgi apparatus, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, focal adhesion, glutamatergic synapse, postsynaptic specialization, intracellular component...
actin filament, microtubule organizing center, cytosol, extracellular exosome, Golgi apparatus, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, focal adhesion, glutamatergic synapse, postsynaptic specialization, intracellular component
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YES proto-oncogene 1, Src family tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc