LYN
Entrez ID: 4067
Full name: LYN proto-oncogene, Src family tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Src: SrcB
Chromosomal location: 8q12.1
Substructure location: Gatekeeper: 319 A-loop: 384...408 G-loop: [N/A] αC-helix: 290...293
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LYN
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic ...
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity).
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GO - Biological processes (BP):
adaptive immune response, B cell homeostasis, B cell receptor signaling pathway, blood coagulation, cell differentiation, cellular response to DNA damage stimulus, cellular response to extracellular stimulus, cellular response to heat, cellular response to retinoic acid, cytokine secretion, dendriti...
adaptive immune response, B cell homeostasis, B cell receptor signaling pathway, blood coagulation, cell differentiation, cellular response to DNA damage stimulus, cellular response to extracellular stimulus, cellular response to heat, cellular response to retinoic acid, cytokine secretion, dendritic cell differentiation, ephrin receptor signaling pathway, erythrocyte differentiation, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, Fc receptor mediated inhibitory signaling pathway, Fc receptor mediated stimulatory signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, histamine secretion by mast cell, immune response-regulating cell surface receptor signaling pathway, innate immune response, intracellular signal transduction, leukocyte migration, lipopolysaccharide-mediated signaling pathway, negative regulation of B cell proliferation, negative regulation of cell population proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of immune response, negative regulation of intracellular signal transduction, negative regulation of MAP kinase activity, negative regulation of mast cell proliferation, negative regulation of myeloid leukocyte differentiation, negative regulation of protein phosphorylation, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of toll-like receptor 4 signaling pathway, neuron projection development, oligodendrocyte development, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, platelet activation, platelet degranulation, positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cellular component movement, positive regulation of dendritic cell apoptotic process, positive regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of glial cell proliferation, positive regulation of mast cell proliferation, positive regulation of neuron projection development, positive regulation of oligodendrocyte progenitor proliferation, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein phosphorylation, positive regulation of Ras protein signal transduction, positive regulation of stress-activated protein kinase signaling cascade, positive regulation of tyrosine phosphorylation of STAT protein, protein autophosphorylation, protein phosphorylation, regulation of B cell apoptotic process, regulation of B cell receptor signaling pathway, regulation of cell adhesion mediated by integrin, regulation of cell population proliferation, regulation of cytokine production, regulation of cytokine secretion, regulation of ERK1 and ERK2 cascade, regulation of erythrocyte differentiation, regulation of inflammatory response, regulation of mast cell activation, regulation of mast cell degranulation, regulation of monocyte chemotaxis, regulation of platelet aggregation, regulation of protein phosphorylation, regulation of release of sequestered calcium ion into cytosol, response to amino acid, response to axon injury, response to carbohydrate, response to drug, response to hormone, response to insulin, response to organic cyclic compound, response to sterol depletion, response to toxic substance, signal transduction, stimulatory C-type lectin receptor signaling pathway, T cell costimulation, tolerance induction to self antigen, toll-like receptor 4 signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, viral process
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GO - Molecular function (MF):
ATP binding, enzyme binding, ephrin receptor binding, gamma-tubulin binding, glycosphingolipid binding, integrin binding, ion channel binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, phosphoprotein binding, phosphorylation-dependent protein binding, platelet-derived ...
ATP binding, enzyme binding, ephrin receptor binding, gamma-tubulin binding, glycosphingolipid binding, integrin binding, ion channel binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, phosphoprotein binding, phosphorylation-dependent protein binding, platelet-derived growth factor receptor binding, protein tyrosine kinase activity, SH3 domain binding, signaling receptor binding, ubiquitin protein ligase binding
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GO - Cellular component (CC):
cytosol, extracellular exosome, Golgi apparatus, mast cell granule, mitochondrial crista, mitochondrial intermembrane space, nucleus, extrinsic component of cytoplasmic side of plasma membrane, integrin alpha2-beta1 complex, plasma membrane, cytoplasm, glutamatergic synapse, intracellular membrane-b...
cytosol, extracellular exosome, Golgi apparatus, mast cell granule, mitochondrial crista, mitochondrial intermembrane space, nucleus, extrinsic component of cytoplasmic side of plasma membrane, integrin alpha2-beta1 complex, plasma membrane, cytoplasm, glutamatergic synapse, intracellular membrane-bounded organelle, membrane raft, perinuclear region of cytoplasm, postsynaptic density, postsynaptic specialization, intracellular component
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LYN proto-oncogene, Src family tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc