MET
Entrez ID: 4233
Full name: MET proto-oncogene, receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Met
Chromosomal location: 7q31
Substructure location: Gatekeeper: 1157 A-loop: 1221...1240, 1242...1248 G-loop: 1085...1092 αC-helix: 1118...1132
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MET
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces auto...
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
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GO - Biological processes (BP):
branching morphogenesis of an epithelial tube, cell surface receptor signaling pathway, endothelial cell morphogenesis, entry of bacterium into host cell, establishment of skin barrier, liver development, MAPK cascade, multicellular organism development, negative regulation of autophagy, negative re...
branching morphogenesis of an epithelial tube, cell surface receptor signaling pathway, endothelial cell morphogenesis, entry of bacterium into host cell, establishment of skin barrier, liver development, MAPK cascade, multicellular organism development, negative regulation of autophagy, negative regulation of guanyl-nucleotide exchange factor activity, negative regulation of hydrogen peroxide-mediated programmed cell death, negative regulation of Rho protein signal transduction, negative regulation of stress fiber assembly, negative regulation of thrombin-activated receptor signaling pathway, neuron differentiation, pancreas development, positive chemotaxis, positive regulation of endothelial cell chemotaxis, positive regulation of kinase activity, positive regulation of microtubule polymerization, positive regulation of protein kinase B signaling, positive regulation of transcription by RNA polymerase II, semaphorin-plexin signaling pathway, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, hepatocyte growth factor-activated receptor activity, identical protein binding, protein phosphatase binding, protein tyrosine kinase activity, semaphorin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, hepatocyte growth factor-activated receptor activity, identical protein binding, protein phosphatase binding, protein tyrosine kinase activity, semaphorin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
extracellular region, basal plasma membrane, integral component of plasma membrane, plasma membrane, cell surface, integral component of membrane, receptor complex...
extracellular region, basal plasma membrane, integral component of plasma membrane, plasma membrane, cell surface, integral component of membrane, receptor complex
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MET proto-oncogene, receptor tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc