HCK
Entrez ID: 3055
Full name: HCK proto-oncogene, Src family tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Src: SrcB
Chromosomal location: 20q11.21
Substructure location: Gatekeeper: 333 A-loop: [N/A] G-loop: 267...274 αC-helix: 299...309
Please click HERE
for better display.
HCK
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and prolifera...
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
View more >>
GO - Biological processes (BP):
cell adhesion, cell differentiation, cytokine-mediated signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, inflammatory response, innate immune response-activating signal transduction, integrin-mediated signaling pathway, interferon-gamma-mediated signaling pathway, leuk...
cell adhesion, cell differentiation, cytokine-mediated signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, inflammatory response, innate immune response-activating signal transduction, integrin-mediated signaling pathway, interferon-gamma-mediated signaling pathway, leukocyte degranulation, leukocyte migration involved in immune response, lipopolysaccharide-mediated signaling pathway, mesoderm development, negative regulation of apoptotic process, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of actin cytoskeleton reorganization, positive regulation of actin filament polymerization, positive regulation of cell population proliferation, protein autophosphorylation, protein phosphorylation, regulation of cell population proliferation, regulation of cell shape, regulation of defense response to virus by virus, regulation of DNA-binding transcription factor activity, regulation of inflammatory response, regulation of phagocytosis, regulation of podosome assembly, respiratory burst after phagocytosis, transmembrane receptor protein tyrosine kinase signaling pathway
View more >>
GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, non-membrane spanning protein tyrosine kinase activity, phosphotyrosine residue binding, protein tyrosine kinase activity, signaling receptor binding
View more >>
GO - Cellular component (CC):
cytoskeleton, cytosol, Golgi apparatus, lysosome, nucleoplasm, caveola, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, cell projection, focal adhesion, transport vesicle...
cytoskeleton, cytosol, Golgi apparatus, lysosome, nucleoplasm, caveola, extrinsic component of cytoplasmic side of plasma membrane, plasma membrane, cell projection, focal adhesion, transport vesicle
View more >>
HCK proto-oncogene, Src family tyrosine kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for HCK in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc