ROS1
Entrez ID: 6098
Full name: ROS proto-oncogene 1, receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Sev
Chromosomal location: 6q22.1
Substructure location: Gatekeeper: 2026 A-loop: 2101...2126 G-loop: 1950...1961 αC-helix: 1988...2002
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ROS1
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR s...
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
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GO - Biological processes (BP):
cell differentiation, columnar/cuboidal epithelial cell development, multicellular organism development, negative regulation of gene expression, peptidyl-tyrosine autophosphorylation, positive regulation of kinase activity, protein phosphorylation, regulation of cell growth, regulation of ERK1 and E...
cell differentiation, columnar/cuboidal epithelial cell development, multicellular organism development, negative regulation of gene expression, peptidyl-tyrosine autophosphorylation, positive regulation of kinase activity, protein phosphorylation, regulation of cell growth, regulation of ERK1 and ERK2 cascade, regulation of phosphate transport, regulation of TOR signaling, signal transduction by protein phosphorylation, spermatogenesis, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, protein phosphatase binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, protein phosphatase binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
integral component of plasma membrane, cell surface, membrane, perinuclear region of cytoplasm, receptor complex...
integral component of plasma membrane, cell surface, membrane, perinuclear region of cytoplasm, receptor complex
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ROS proto-oncogene 1, receptor tyrosine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc