WEE2
Entrez ID: 494551
Full name: WEE2 oocyte meiosis inhibiting kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WEE: WEE1
Chromosomal location: 7q34
Substructure location: Gatekeeper: 289 A-loop: 379...398 G-loop: [N/A] αC-helix: [N/A]
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WEE2
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at d...
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
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GO - Biological processes (BP):
female meiotic nuclear division, female pronucleus assembly, mitotic cell cycle checkpoint, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of oocyte maturation, positive regulation of phosphorylation, regulation of fertilization, regulation of m...
female meiotic nuclear division, female pronucleus assembly, mitotic cell cycle checkpoint, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of oocyte maturation, positive regulation of phosphorylation, regulation of fertilization, regulation of meiosis I
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, protein tyrosine kinase activity...
ATP binding, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
nucleoplasm, nucleus, cytoplasm...
nucleoplasm, nucleus, cytoplasm
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WEE2 oocyte meiosis inhibiting kinase
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*NOTE: the Kaplan plots were collected from OncoLnc