ARAF
Entrez ID: 369
Full name: A-Raf proto-oncogene, serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RAF: RAF
Chromosomal location: Xp11.3
Substructure location: Gatekeeper: 382 A-loop: 446...471 G-loop: [N/A] αC-helix: [N/A]
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ARAF
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade....
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
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GO - Biological processes (BP):
cellular protein modification process, MAPK cascade, negative regulation of apoptotic process, positive regulation of peptidyl-serine phosphorylation, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of TOR signaling...
cellular protein modification process, MAPK cascade, negative regulation of apoptotic process, positive regulation of peptidyl-serine phosphorylation, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of TOR signaling
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, mitochondrion...
cytosol, mitochondrion
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A-Raf proto-oncogene, serine/threonine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc