BCR
Entrez ID: 613
Full name: BCR activator of RhoGEF and GTPase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: BCR
Chromosomal location: 22q11.23
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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BCR
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading ...
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119).
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GO - Biological processes (BP):
actin cytoskeleton organization, activation of GTPase activity, brain development, cellular response to lipopolysaccharide, definitive hemopoiesis, focal adhesion assembly, homeostasis of number of cells, inner ear morphogenesis, intracellular protein transmembrane transport, keratinocyte differenti...
actin cytoskeleton organization, activation of GTPase activity, brain development, cellular response to lipopolysaccharide, definitive hemopoiesis, focal adhesion assembly, homeostasis of number of cells, inner ear morphogenesis, intracellular protein transmembrane transport, keratinocyte differentiation, modulation of chemical synaptic transmission, negative regulation of blood vessel remodeling, negative regulation of cellular extravasation, negative regulation of inflammatory response, negative regulation of neutrophil degranulation, negative regulation of reactive oxygen species metabolic process, negative regulation of respiratory burst, neuromuscular process controlling balance, platelet-derived growth factor receptor signaling pathway, positive regulation of phagocytosis, protein autophosphorylation, protein phosphorylation, regulation of cell cycle, regulation of nitrogen compound metabolic process, regulation of Rho protein signal transduction, regulation of small GTPase mediated signal transduction, regulation of vascular permeability, renal system process, signal transduction, small GTPase mediated signal transduction
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GO - Molecular function (MF):
ATP binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, kinase activity, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity...
ATP binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, kinase activity, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity
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GO - Cellular component (CC):
cytosol, extracellular exosome, plasma membrane, axon, cell junction, dendritic spine, glutamatergic synapse, membrane, postsynaptic density, postsynaptic density, intracellular component, protein-containing complex, Schaffer collateral - CA1 synapse...
cytosol, extracellular exosome, plasma membrane, axon, cell junction, dendritic spine, glutamatergic synapse, membrane, postsynaptic density, postsynaptic density, intracellular component, protein-containing complex, Schaffer collateral - CA1 synapse
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BCR activator of RhoGEF and GTPase
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for BCR in
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*NOTE: the Kaplan plots were collected from OncoLnc