FGFR1
Entrez ID: 2260
Full name: fibroblast growth factor receptor 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: FGFR
Chromosomal location: 8p11.23
Substructure location: Gatekeeper: 561 A-loop: 640...665 G-loop: 484...490 αC-helix: 522...538
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FGFR1
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic ...
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
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GO - Biological processes (BP):
angiogenesis, auditory receptor cell development, branching involved in salivary gland morphogenesis, cell maturation, cell migration, chondrocyte differentiation, chordate embryonic development, embryonic limb morphogenesis, fibroblast growth factor receptor signaling pathway, fibroblast growth fac...
angiogenesis, auditory receptor cell development, branching involved in salivary gland morphogenesis, cell maturation, cell migration, chondrocyte differentiation, chordate embryonic development, embryonic limb morphogenesis, fibroblast growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, inner ear morphogenesis, in utero embryonic development, lung-associated mesenchyme development, MAPK cascade, mesenchymal cell differentiation, midbrain development, middle ear morphogenesis, multicellular organism development, negative regulation of fibroblast growth factor production, negative regulation of transcription by RNA polymerase II, neuron migration, organ induction, outer ear morphogenesis, paraxial mesoderm development, peptidyl-tyrosine phosphorylation, phosphatidylinositol-mediated signaling, positive regulation of blood vessel endothelial cell migration, positive regulation of cardiac muscle cell proliferation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of endothelial cell chemotaxis to fibroblast growth factor, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of MAP kinase activity, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of mesenchymal cell proliferation, positive regulation of mitotic cell cycle DNA replication, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of parathyroid hormone secretion, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase activity, positive regulation of phospholipase C activity, positive regulation of protein kinase B signaling, positive regulation of vascular endothelial cell proliferation, protein autophosphorylation, protein phosphorylation, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, regulation of cell differentiation, regulation of extrinsic apoptotic signaling pathway in absence of ligand, regulation of lateral mesodermal cell fate specification, regulation of phosphate transport, sensory perception of sound, skeletal system development, skeletal system morphogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, ureteric bud development, ventricular zone neuroblast division, vitamin D3 metabolic process
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GO - Molecular function (MF):
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, heparin binding, identical protein binding, protein homodimerization activity, protein tyrosine kinase activity, receptor-receptor interaction, SH2 domain binding, transmembrane receptor protein tyro...
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, heparin binding, identical protein binding, protein homodimerization activity, protein tyrosine kinase activity, receptor-receptor interaction, SH2 domain binding, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, extracellular region, nucleus, integral component of plasma membrane, plasma membrane, cytoplasmic vesicle, integral component of membrane, receptor complex...
cytosol, extracellular region, nucleus, integral component of plasma membrane, plasma membrane, cytoplasmic vesicle, integral component of membrane, receptor complex
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fibroblast growth factor receptor 1
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*NOTE: the Kaplan plots were collected from OncoLnc