CDK4
Entrez ID: 1019
Full name: cyclin dependent kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CDK4
Chromosomal location: 12q14.1
Substructure location: Gatekeeper: 93 A-loop: [N/A] G-loop: [N/A] αC-helix: 51...63
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CDK4
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F compl...
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
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GO - Biological processes (BP):
adipose tissue development, animal organ regeneration, cell division, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, circadian rhythm, G1/S trans...
adipose tissue development, animal organ regeneration, cell division, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, circadian rhythm, G1/S transition of mitotic cell cycle, lens development in camera-type eye, negative regulation of cell cycle arrest, negative regulation of G1/S transition of mitotic cell cycle, positive regulation of apoptotic process, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of cell size, positive regulation of fibroblast proliferation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of translation, protein phosphorylation, regulation of gene expression, regulation of insulin receptor signaling pathway, regulation of lipid biosynthetic process, regulation of lipid catabolic process, regulation of multicellular organism growth, response to drug, response to hyperoxia, response to lead ion, response to testosterone, response to toxic substance, signal transduction, transcription initiation from RNA polymerase II promoter
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GO - Molecular function (MF):
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein-containing complex binding...
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein-containing complex binding
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GO - Cellular component (CC):
cytosol, nuclear membrane, nucleolus, nucleoplasm, nucleus, bicellular tight junction, chromatin, cyclin D2-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, perinuclear region of cytoplasm, transcription factor complex...
cytosol, nuclear membrane, nucleolus, nucleoplasm, nucleus, bicellular tight junction, chromatin, cyclin D2-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, perinuclear region of cytoplasm, transcription factor complex
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cyclin dependent kinase 4
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A-loop
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Kaplan plot for CDK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc