BRAF
Entrez ID: 673
Full name: B-Raf proto-oncogene, serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RAF: RAF
Chromosomal location: 7q34
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 464...471 αC-helix: 492...506
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BRAF
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal ...
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179).
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GO - Biological processes (BP):
activation of MAPKK activity, animal organ morphogenesis, cellular response to calcium ion, epidermal growth factor receptor signaling pathway, establishment of protein localization to membrane, MAPK cascade, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, pos...
activation of MAPKK activity, animal organ morphogenesis, cellular response to calcium ion, epidermal growth factor receptor signaling pathway, establishment of protein localization to membrane, MAPK cascade, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of glucose transmembrane transport, positive regulation of peptidyl-serine phosphorylation, protein phosphorylation, trehalose metabolism in response to stress
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GO - Molecular function (MF):
ATP binding, calcium ion binding, identical protein binding, protein kinase activity, protein serine/threonine kinase activity, scaffold protein binding...
ATP binding, calcium ion binding, identical protein binding, protein kinase activity, protein serine/threonine kinase activity, scaffold protein binding
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GO - Cellular component (CC):
cytosol, mitochondrion, nucleus, plasma membrane, intracellular membrane-bounded organelle...
cytosol, mitochondrion, nucleus, plasma membrane, intracellular membrane-bounded organelle
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B-Raf proto-oncogene, serine/threonine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc