NME1
Entrez ID: 4830
Full name: NME/NM23 nucleoside diphosphate kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NDK
Chromosomal location: 17q21.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NME1
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, gera...
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
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GO - Biological processes (BP):
cellular response to drug, cellular response to fatty acid, cellular response to glucose stimulus, CTP biosynthetic process, endocytosis, GTP biosynthetic process, hippocampus development, lactation, negative regulation of cell population proliferation, negative regulation of gene expression, negati...
cellular response to drug, cellular response to fatty acid, cellular response to glucose stimulus, CTP biosynthetic process, endocytosis, GTP biosynthetic process, hippocampus development, lactation, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of myeloid leukocyte differentiation, nucleobase-containing small molecule interconversion, positive regulation of DNA binding, positive regulation of epithelial cell proliferation, positive regulation of neuron projection development, purine nucleotide metabolic process, pyrimidine nucleotide metabolic process, regulation of apoptotic process, response to amine, response to cAMP, response to testosterone, UTP biosynthetic process
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GO - Molecular function (MF):
ATP binding, deoxyribonuclease activity, enzyme binding, gamma-tubulin binding, GTP binding, identical protein binding, intermediate filament binding, magnesium ion binding, nucleoside diphosphate kinase activity, ribosomal small subunit binding, RNA binding, RNA polymerase II regulatory region sequ...
ATP binding, deoxyribonuclease activity, enzyme binding, gamma-tubulin binding, GTP binding, identical protein binding, intermediate filament binding, magnesium ion binding, nucleoside diphosphate kinase activity, ribosomal small subunit binding, RNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, single-stranded DNA binding
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GO - Cellular component (CC):
centrosome, intermediate filament, cytosol, extracellular exosome, mitochondrial outer membrane, nucleus, ruffle membrane, cell, cytoplasm, membrane, perinuclear region of cytoplasm...
centrosome, intermediate filament, cytosol, extracellular exosome, mitochondrial outer membrane, nucleus, ruffle membrane, cell, cytoplasm, membrane, perinuclear region of cytoplasm
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NME/NM23 nucleoside diphosphate kinase 1
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A-loop
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αC-helix
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Kaplan plot for NME1 in
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*NOTE: the Kaplan plots were collected from OncoLnc