NPR1
Entrez ID: 4881
Full name: natriuretic peptide receptor 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: RGC: RGC
Chromosomal location: 1q21.3
Substructure location: Gatekeeper: 612 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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NPR1
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand....
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
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GO - Biological processes (BP):
body fluid secretion, cell surface receptor signaling pathway, cGMP biosynthetic process, cGMP-mediated signaling, dopamine metabolic process, negative regulation of angiogenesis, negative regulation of cell growth, negative regulation of smooth muscle cell proliferation, positive regulation of cGMP...
body fluid secretion, cell surface receptor signaling pathway, cGMP biosynthetic process, cGMP-mediated signaling, dopamine metabolic process, negative regulation of angiogenesis, negative regulation of cell growth, negative regulation of smooth muscle cell proliferation, positive regulation of cGMP-mediated signaling, positive regulation of renal sodium excretion, positive regulation of urine volume, receptor guanylyl cyclase signaling pathway, regulation of blood pressure, regulation of blood vessel diameter, regulation of cardiac conduction, regulation of vascular permeability, signal transduction
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GO - Molecular function (MF):
ATP binding, G protein-coupled peptide receptor activity, GTP binding, guanylate cyclase activity, hormone binding, natriuretic peptide receptor activity, peptide hormone binding, peptide receptor activity, protein kinase activity, protein kinase binding...
ATP binding, G protein-coupled peptide receptor activity, GTP binding, guanylate cyclase activity, hormone binding, natriuretic peptide receptor activity, peptide hormone binding, peptide receptor activity, protein kinase activity, protein kinase binding
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GO - Cellular component (CC):
plasma membrane, integral component of membrane, receptor complex...
plasma membrane, integral component of membrane, receptor complex
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natriuretic peptide receptor 1
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*NOTE: the Kaplan plots were collected from OncoLnc