PDGFRA
Entrez ID: 5156
Full name: platelet derived growth factor receptor alpha
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: PDGFR
Chromosomal location: 4q12
Substructure location: Gatekeeper: 674 A-loop: 835...860 G-loop: 599...605 αC-helix: 635...651
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PDGFRA
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an ...
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
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GO - Biological processes (BP):
adrenal gland development, cardiac myofibril assembly, cell activation, cell chemotaxis, cellular response to amino acid stimulus, cellular response to reactive oxygen species, embryonic cranial skeleton morphogenesis, embryonic digestive tract morphogenesis, embryonic skeletal system morphogenesis,...
adrenal gland development, cardiac myofibril assembly, cell activation, cell chemotaxis, cellular response to amino acid stimulus, cellular response to reactive oxygen species, embryonic cranial skeleton morphogenesis, embryonic digestive tract morphogenesis, embryonic skeletal system morphogenesis, estrogen metabolic process, extracellular matrix organization, face morphogenesis, hematopoietic progenitor cell differentiation, in utero embryonic development, Leydig cell differentiation, lung development, luteinization, male genitalia development, MAPK cascade, metanephric glomerular capillary formation, multicellular organism development, negative regulation of platelet activation, odontogenesis of dentin-containing tooth, peptidyl-tyrosine phosphorylation, phosphatidylinositol-mediated signaling, platelet aggregation, platelet-derived growth factor receptor-alpha signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, positive regulation of ERK1 and ERK2 cascade, positive regulation of fibroblast proliferation, positive regulation of kinase activity, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase C activity, positive regulation of protein kinase B signaling, protein autophosphorylation, regulation of actin cytoskeleton reorganization, regulation of chemotaxis, regulation of mesenchymal stem cell differentiation, retina vasculature development in camera-type eye, roof of mouth development, signal transduction involved in regulation of gene expression, transmembrane receptor protein tyrosine kinase signaling pathway, viral process, wound healing
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GO - Molecular function (MF):
ATP binding, growth factor binding, platelet-derived growth factor alpha-receptor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein-containing complex binding, protein homodimerization activity, protein kinase activity, transmembrane receptor ...
ATP binding, growth factor binding, platelet-derived growth factor alpha-receptor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein-containing complex binding, protein homodimerization activity, protein kinase activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial growth factor binding
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GO - Cellular component (CC):
Golgi apparatus, nucleoplasm, nucleus, external side of plasma membrane, integral component of plasma membrane, intrinsic component of plasma membrane, plasma membrane, cell, cell junction, cilium, cytoplasm, membrane, microvillus, protein-containing complex, receptor complex...
Golgi apparatus, nucleoplasm, nucleus, external side of plasma membrane, integral component of plasma membrane, intrinsic component of plasma membrane, plasma membrane, cell, cell junction, cilium, cytoplasm, membrane, microvillus, protein-containing complex, receptor complex
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platelet derived growth factor receptor alpha
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*NOTE: the Kaplan plots were collected from OncoLnc