FER
Entrez ID: 2241
Full name: FER tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Fer
Chromosomal location: 5q21.3
Substructure location: Gatekeeper: 637 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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FER
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts do...
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
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GO - Biological processes (BP):
actin cytoskeleton reorganization, cell adhesion, cell-cell adhesion mediated by cadherin, cell differentiation, cell migration, cell population proliferation, cellular response to insulin stimulus, cellular response to macrophage colony-stimulating factor stimulus, cellular response to reactive oxy...
actin cytoskeleton reorganization, cell adhesion, cell-cell adhesion mediated by cadherin, cell differentiation, cell migration, cell population proliferation, cellular response to insulin stimulus, cellular response to macrophage colony-stimulating factor stimulus, cellular response to reactive oxygen species, chemotaxis, cytokine-mediated signaling pathway, diapedesis, extracellular matrix-cell signaling, Fc-epsilon receptor signaling pathway, insulin receptor signaling pathway via phosphatidylinositol 3-kinase, interleukin-6-mediated signaling pathway, intracellular signal transduction, Kit signaling pathway, microtubule cytoskeleton organization, negative regulation of mast cell activation involved in immune response, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of actin filament polymerization, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of NF-kappaB transcription factor activity, protein autophosphorylation, protein phosphorylation, regulation of cell population proliferation, regulation of epidermal growth factor receptor signaling pathway, regulation of fibroblast migration, regulation of lamellipodium assembly, regulation of mast cell degranulation, regulation of protein phosphorylation, response to lipopolysaccharide, response to platelet-derived growth factor, substrate adhesion-dependent cell spreading, transmembrane receptor protein tyrosine kinase signaling pathway, tyrosine phosphorylation of STAT protein
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GO - Molecular function (MF):
ATP binding, epidermal growth factor receptor binding, lipid binding, non-membrane spanning protein tyrosine kinase activity, protein phosphatase 1 binding, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, epidermal growth factor receptor binding, lipid binding, non-membrane spanning protein tyrosine kinase activity, protein phosphatase 1 binding, protein tyrosine kinase activity, signaling receptor binding
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GO - Cellular component (CC):
cytoskeleton, cytosol, nucleus, extrinsic component of cytoplasmic side of plasma membrane, cell cortex, cell junction, cell projection, cytoplasm...
cytoskeleton, cytosol, nucleus, extrinsic component of cytoplasmic side of plasma membrane, cell cortex, cell junction, cell projection, cytoplasm
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FER tyrosine kinase
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Kaplan plot for FER in
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*NOTE: the Kaplan plots were collected from OncoLnc