PRKACA
Entrez ID: 5566
Full name: protein kinase cAMP-activated catalytic subunit alpha
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKA
Chromosomal location: 19p13.12
Substructure location: Gatekeeper: 121 A-loop: 184...204 G-loop: 50...59 αC-helix: 77...82
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PRKACA
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, AB...
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490).
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GO - Biological processes (BP):
activation of protein kinase A activity, blood coagulation, calcium-mediated signaling using intracellular calcium source, cell communication by electrical coupling involved in cardiac conduction, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to...
activation of protein kinase A activity, blood coagulation, calcium-mediated signaling using intracellular calcium source, cell communication by electrical coupling involved in cardiac conduction, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to parathyroid hormone stimulus, ciliary basal body-plasma membrane docking, cytokine-mediated signaling pathway, G2/M transition of mitotic cell cycle, high-density lipoprotein particle assembly, mesoderm formation, modulation of chemical synaptic transmission, mRNA processing, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, neural tube closure, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of cell cycle arrest, positive regulation of protein export from nucleus, protein autophosphorylation, protein kinase A signaling, protein phosphorylation, regulation of bicellular tight junction assembly, regulation of cardiac conduction, regulation of cardiac muscle contraction, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of cytosolic calcium ion concentration, regulation of G2/M transition of mitotic cell cycle, regulation of heart rate, regulation of macroautophagy, regulation of osteoblast differentiation, regulation of proteasomal protein catabolic process, regulation of protein binding, regulation of protein processing, regulation of ryanodine-sensitive calcium-release channel activity, renal water homeostasis, sperm capacitation, stimulatory C-type lectin receptor signaling pathway
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GO - Molecular function (MF):
AMP-activated protein kinase activity, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding, manganese ion binding, protein domain specific binding, protein kinase activity, protein kinase A regulatory subunit binding, protein kinase binding, protein serine/threonine/tyrosine k...
AMP-activated protein kinase activity, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding, manganese ion binding, protein domain specific binding, protein kinase activity, protein kinase A regulatory subunit binding, protein kinase binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, ubiquitin protein ligase binding
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GO - Cellular component (CC):
centrosome, cytosol, extracellular exosome, intercellular bridge, mitochondrion, nuclear speck, nucleoplasm, nucleus, plasma membrane raft, acrosomal vesicle, calcium channel complex, cAMP-dependent protein kinase complex, cell, ciliary base, cytoplasm, dendritic spine, membrane, neuromuscular junct...
centrosome, cytosol, extracellular exosome, intercellular bridge, mitochondrion, nuclear speck, nucleoplasm, nucleus, plasma membrane raft, acrosomal vesicle, calcium channel complex, cAMP-dependent protein kinase complex, cell, ciliary base, cytoplasm, dendritic spine, membrane, neuromuscular junction, nucleotide-activated protein kinase complex, perinuclear region of cytoplasm, sperm flagellum, sperm midpiece
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protein kinase cAMP-activated catalytic subunit alpha
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Kaplan plot for PRKACA in
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*NOTE: the Kaplan plots were collected from OncoLnc