FLT1
Entrez ID: 2321
Full name: fms related receptor tyrosine kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: VEGFR
Chromosomal location: 13q12.3
Substructure location: Gatekeeper: 909 A-loop: 1039...1064 G-loop: 833...839 αC-helix: 849...851
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FLT1
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essent...
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
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GO - Biological processes (BP):
blood vessel morphogenesis, cell differentiation, cell migration, cellular response to vascular endothelial growth factor stimulus, embryonic morphogenesis, monocyte chemotaxis, multicellular organism development, negative regulation of vascular endothelial cell proliferation, peptidyl-tyrosine phos...
blood vessel morphogenesis, cell differentiation, cell migration, cellular response to vascular endothelial growth factor stimulus, embryonic morphogenesis, monocyte chemotaxis, multicellular organism development, negative regulation of vascular endothelial cell proliferation, peptidyl-tyrosine phosphorylation, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of MAP kinase activity, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of phospholipase C activity, positive regulation of vascular endothelial growth factor receptor signaling pathway, protein autophosphorylation, sprouting angiogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, vascular endothelial growth factor receptor-1 signaling pathway, vascular endothelial growth factor receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, growth factor binding, placental growth factor-activated receptor activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial growth factor binding, VEGF-A-activated receptor activity, VEGF-B-act...
ATP binding, growth factor binding, placental growth factor-activated receptor activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor-activated receptor activity, vascular endothelial growth factor binding, VEGF-A-activated receptor activity, VEGF-B-activated receptor activity
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GO - Cellular component (CC):
actin cytoskeleton, endosome, extracellular space, integral component of plasma membrane, plasma membrane, focal adhesion, receptor complex...
actin cytoskeleton, endosome, extracellular space, integral component of plasma membrane, plasma membrane, focal adhesion, receptor complex
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fms related receptor tyrosine kinase 1
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Kaplan plot for FLT1 in
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*NOTE: the Kaplan plots were collected from OncoLnc