CSNK2A2
Entrez ID: 1459
Full name: casein kinase 2 alpha 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: CK2
Chromosomal location: 16q21
Substructure location: Gatekeeper: 114 A-loop: 175...185, 190...197 G-loop: [N/A] αC-helix: 76...88
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CSNK2A2
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and ...
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
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GO - Biological processes (BP):
apoptotic process, cell cycle, cerebral cortex development, liver regeneration, macroautophagy, negative regulation of apoptotic signaling pathway, negative regulation of ubiquitin-dependent protein catabolic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, phosphatidylc...
apoptotic process, cell cycle, cerebral cortex development, liver regeneration, macroautophagy, negative regulation of apoptotic signaling pathway, negative regulation of ubiquitin-dependent protein catabolic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, phosphatidylcholine biosynthetic process, positive regulation of protein targeting to mitochondrion, protein folding, regulation of autophagy of mitochondrion, regulation of cell cycle, regulation of chromosome separation, regulation of signal transduction by p53 class mediator, spermatogenesis, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, protein N-terminus binding, protein serine/threonine kinase activity...
ATP binding, protein N-terminus binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, plasma membrane, acrosomal vesicle, chromatin...
cytosol, nucleoplasm, nucleus, plasma membrane, acrosomal vesicle, chromatin
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casein kinase 2 alpha 2
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Kaplan plot for CSNK2A2 in
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*NOTE: the Kaplan plots were collected from OncoLnc