MAK
Entrez ID: 4117
Full name: male germ cell associated kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: RCK: MAK
Chromosomal location: 6p24.2
Substructure location: Gatekeeper: 79 A-loop: 142...152, 155...164 G-loop: [N/A] αC-helix: [N/A]
Please click HERE
for better display.
MAK
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role...
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
View more >>
GO - Biological processes (BP):
cell differentiation, cilium assembly, intracellular signal transduction, intraciliary transport, multicellular organism development, negative regulation of non-motile cilium assembly, photoreceptor cell maintenance, protein autophosphorylation, protein phosphorylation, regulation of gene expression...
cell differentiation, cilium assembly, intracellular signal transduction, intraciliary transport, multicellular organism development, negative regulation of non-motile cilium assembly, photoreceptor cell maintenance, protein autophosphorylation, protein phosphorylation, regulation of gene expression, spermatogenesis
View more >>
GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, transcription coactivator activity...
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, transcription coactivator activity
View more >>
GO - Cellular component (CC):
axoneme, centrosome, mitotic spindle, nucleus, cilium, cytoplasm, midbody, motile cilium, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment...
axoneme, centrosome, mitotic spindle, nucleus, cilium, cytoplasm, midbody, motile cilium, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment
View more >>
male germ cell associated kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for MAK in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc