TAF1
Entrez ID: 6872
Full name: TATA-box binding protein associated factor 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: TAF1
Chromosomal location: Xq13.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TAF1
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads t...
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).
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GO - Biological processes (BP):
cell cycle, cellular response to ATP, cellular response to DNA damage stimulus, cellular response to UV, DNA-templated transcription, initiation, midbrain development, negative regulation of DNA-binding transcription factor activity, negative regulation of gene expression, negative regulation of pro...
cell cycle, cellular response to ATP, cellular response to DNA damage stimulus, cellular response to UV, DNA-templated transcription, initiation, midbrain development, negative regulation of DNA-binding transcription factor activity, negative regulation of gene expression, negative regulation of protein autoubiquitination, negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding, negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage, negative regulation of ubiquitin-dependent protein catabolic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of androgen receptor activity, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein binding, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation from RNA polymerase II promoter, protein autophosphorylation, protein phosphorylation, protein polyubiquitination, protein stabilization, regulation of cell cycle G1/S phase transition, regulation of signal transduction by p53 class mediator, regulation of transcription, DNA-templated, regulation of transcription initiation from RNA polymerase II promoter, RNA polymerase II preinitiation complex assembly, transcription by RNA polymerase II, transcription factor catabolic process, transcription initiation from RNA polymerase II promoter, ubiquitin-dependent protein catabolic process, viral process
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GO - Molecular function (MF):
ATP binding, histone acetyltransferase activity, kinase activity, lysine-acetylated histone binding, nuclear hormone receptor binding, p53 binding, protein heterodimerization activity, protein serine/threonine kinase activity, RNA polymerase II general transcription initiation factor activity, RNA p...
ATP binding, histone acetyltransferase activity, kinase activity, lysine-acetylated histone binding, nuclear hormone receptor binding, p53 binding, protein heterodimerization activity, protein serine/threonine kinase activity, RNA polymerase II general transcription initiation factor activity, RNA polymerase II-specific DNA-binding transcription factor binding, sequence-specific DNA binding, TBP-class protein binding, transcription coactivator activity, transcription factor binding, ubiquitin conjugating enzyme activity
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GO - Cellular component (CC):
MLL1 complex, nuclear chromatin, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor complex...
MLL1 complex, nuclear chromatin, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor complex
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TATA-box binding protein associated factor 1
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Gatekeeper
A-loop
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αC-helix
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Kaplan plot for TAF1 in
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*NOTE: the Kaplan plots were collected from OncoLnc