FGFR2
Entrez ID: 2263
Full name: fibroblast growth factor receptor 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: FGFR
Chromosomal location: 10q26.13
Substructure location: Gatekeeper: 564 A-loop: 643...668 G-loop: 487...496 αC-helix: 525...541
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FGFR2
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblas...
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
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GO - Biological processes (BP):
angiogenesis, animal organ morphogenesis, apoptotic process, axonogenesis, bone development, bone mineralization, bone morphogenesis, branch elongation involved in salivary gland morphogenesis, branching involved in labyrinthine layer morphogenesis, branching involved in prostate gland morphogenesis...
angiogenesis, animal organ morphogenesis, apoptotic process, axonogenesis, bone development, bone mineralization, bone morphogenesis, branch elongation involved in salivary gland morphogenesis, branching involved in labyrinthine layer morphogenesis, branching involved in prostate gland morphogenesis, branching involved in salivary gland morphogenesis, branching morphogenesis of a nerve, bud elongation involved in lung branching, cell-cell signaling, cell fate commitment, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, digestive tract development, embryonic cranial skeleton morphogenesis, embryonic digestive tract morphogenesis, embryonic organ development, embryonic organ morphogenesis, embryonic pattern specification, endochondral bone growth, epidermis morphogenesis, epithelial cell differentiation, epithelial cell proliferation involved in salivary gland morphogenesis, epithelial to mesenchymal transition, fibroblast growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway involved in hemopoiesis, fibroblast growth factor receptor signaling pathway involved in mammary gland specification, fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell, fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow, gland morphogenesis, hair follicle morphogenesis, inner ear morphogenesis, in utero embryonic development, lacrimal gland development, lateral sprouting from an epithelium, limb bud formation, lung alveolus development, lung-associated mesenchyme development, lung development, lung lobe morphogenesis, mammary gland bud formation, MAPK cascade, membranous septum morphogenesis, mesenchymal cell differentiation, mesenchymal cell differentiation involved in lung development, mesenchymal cell proliferation involved in lung development, mesodermal cell differentiation, midbrain development, morphogenesis of embryonic epithelium, multicellular organism development, negative regulation of epithelial cell proliferation, negative regulation of transcription by RNA polymerase II, odontogenesis, orbitofrontal cortex development, organ growth, otic vesicle formation, outflow tract septum morphogenesis, peptidyl-tyrosine phosphorylation, positive regulation of canonical Wnt signaling pathway, positive regulation of cardiac muscle cell proliferation, positive regulation of cell cycle, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation involved in lung morphogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of mesenchymal cell proliferation, positive regulation of phospholipase activity, positive regulation of protein kinase B signaling, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of Wnt signaling pathway, post-embryonic development, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, prostate epithelial cord elongation, prostate gland morphogenesis, protein autophosphorylation, pyramidal neuron development, regulation of ERK1 and ERK2 cascade, regulation of morphogenesis of a branching structure, regulation of osteoblast differentiation, regulation of osteoblast proliferation, regulation of smoothened signaling pathway, regulation of smooth muscle cell differentiation, reproductive structure development, response to ethanol, response to lipopolysaccharide, skeletal system morphogenesis, squamous basal epithelial stem cell differentiation involved in prostate gland acinus development, transmembrane receptor protein tyrosine kinase signaling pathway, ureteric bud development, ventricular cardiac muscle tissue morphogenesis, ventricular zone neuroblast division, wound healing
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GO - Molecular function (MF):
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, heparin binding, identical protein binding, protein homodimerization activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, heparin binding, identical protein binding, protein homodimerization activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
extracellular region, Golgi apparatus, nucleus, integral component of plasma membrane, plasma membrane, cell cortex, cell surface, cytoplasm, cytoplasmic vesicle, excitatory synapse, integral component of membrane, membrane, receptor complex...
extracellular region, Golgi apparatus, nucleus, integral component of plasma membrane, plasma membrane, cell cortex, cell surface, cytoplasm, cytoplasmic vesicle, excitatory synapse, integral component of membrane, membrane, receptor complex
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fibroblast growth factor receptor 2
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*NOTE: the Kaplan plots were collected from OncoLnc