ERBB3
Entrez ID: 2065
Full name: erb-b2 receptor tyrosine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: EGFR
Chromosomal location: 12q13.2
Substructure location: Gatekeeper: 787 A-loop: [N/A] G-loop: 714...724 αC-helix: 758...764
Please click HERE
for better display.
ERBB3
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed...
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
View more >>
GO - Biological processes (BP):
cranial nerve development, endocardial cushion development, ERBB2 signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, heart development, MAPK cascade, multicellular organism development, negative regulation of cell adhesion, negative regulation of neuron apoptotic process,...
cranial nerve development, endocardial cushion development, ERBB2 signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, heart development, MAPK cascade, multicellular organism development, negative regulation of cell adhesion, negative regulation of neuron apoptotic process, negative regulation of secretion, negative regulation of signal transduction, nervous system development, neuron apoptotic process, peripheral nervous system development, phosphatidylinositol 3-kinase signaling, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of cardiac muscle tissue development, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein kinase B signaling, positive regulation of protein tyrosine kinase activity, regulation of cell motility, regulation of cell population proliferation, Schwann cell differentiation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing
View more >>
GO - Molecular function (MF):
ATP binding, ErbB-3 class receptor binding, growth factor binding, identical protein binding, neuregulin binding, neuregulin receptor activity, protein heterodimerization activity, protein tyrosine kinase activator activity, transmembrane receptor protein tyrosine kinase activity, transmembrane sign...
ATP binding, ErbB-3 class receptor binding, growth factor binding, identical protein binding, neuregulin binding, neuregulin receptor activity, protein heterodimerization activity, protein tyrosine kinase activator activity, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity, ubiquitin protein ligase binding
View more >>
GO - Cellular component (CC):
extracellular space, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, ERBB3:ERBB2 complex, integral component of plasma membrane, lateral plasma membrane, plasma membrane, receptor complex...
extracellular space, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, ERBB3:ERBB2 complex, integral component of plasma membrane, lateral plasma membrane, plasma membrane, receptor complex
View more >>
erb-b2 receptor tyrosine kinase 3
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for ERBB3 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc