NME2
Entrez ID: 4831
Full name: NME/NM23 nucleoside diphosphate kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NDK
Chromosomal location: 17q21.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NME2
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMe...
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III1 region of the MYC gene promoter. Does not bind to duplex NHE III1 (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858).
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GO - Biological processes (BP):
adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell adhesion, cellular response to fatty acid, cellular response to glucose stimulus, cellular response to oxidative stress, CTP biosynthetic process, GTP biosynthetic process, integrin-mediated signaling pathway, negative r...
adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell adhesion, cellular response to fatty acid, cellular response to glucose stimulus, cellular response to oxidative stress, CTP biosynthetic process, GTP biosynthetic process, integrin-mediated signaling pathway, negative regulation of apoptotic process, negative regulation of myeloid leukocyte differentiation, neutrophil degranulation, nucleobase-containing small molecule interconversion, nucleoside diphosphate phosphorylation, nucleoside triphosphate biosynthetic process, positive regulation of epithelial cell proliferation, positive regulation of keratinocyte differentiation, positive regulation of neuron projection development, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, protein autophosphorylation, purine nucleotide metabolic process, pyrimidine nucleotide metabolic process, regulation of apoptotic process, regulation of epidermis development, response to growth hormone, UTP biosynthetic process
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GO - Molecular function (MF):
ATP binding, DNA binding, enzyme binding, fatty acid binding, GDP binding, G-quadruplex DNA binding, identical protein binding, intermediate filament binding, metal ion binding, nucleoside diphosphate kinase activity, protein histidine kinase activity, protein serine/threonine kinase activity, trans...
ATP binding, DNA binding, enzyme binding, fatty acid binding, GDP binding, G-quadruplex DNA binding, identical protein binding, intermediate filament binding, metal ion binding, nucleoside diphosphate kinase activity, protein histidine kinase activity, protein serine/threonine kinase activity, transcription coactivator activity
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GO - Cellular component (CC):
intermediate filament, cytosol, extracellular exosome, extracellular region, mitochondrial membrane, nucleus, cell, cell periphery, cytoplasm, ficolin-1-rich granule lumen, lamellipodium, perinuclear region of cytoplasm, ruffle, secretory granule lumen...
intermediate filament, cytosol, extracellular exosome, extracellular region, mitochondrial membrane, nucleus, cell, cell periphery, cytoplasm, ficolin-1-rich granule lumen, lamellipodium, perinuclear region of cytoplasm, ruffle, secretory granule lumen
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NME/NM23 nucleoside diphosphate kinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
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Kaplan plot for NME2 in
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*NOTE: the Kaplan plots were collected from OncoLnc