FGFR4
Entrez ID: 2264
Full name: fibroblast growth factor receptor 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: FGFR
Chromosomal location: 5q35.2
Substructure location: Gatekeeper: 550 A-loop: [N/A] G-loop: 472...482 αC-helix: 511...527
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FGFR4
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeosta...
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
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GO - Biological processes (BP):
cell migration, cholesterol homeostasis, fibroblast growth factor receptor signaling pathway, glucose homeostasis, MAPK cascade, multicellular organism development, peptidyl-tyrosine phosphorylation, phosphate ion homeostasis, positive regulation of catalytic activity, positive regulation of cell po...
cell migration, cholesterol homeostasis, fibroblast growth factor receptor signaling pathway, glucose homeostasis, MAPK cascade, multicellular organism development, peptidyl-tyrosine phosphorylation, phosphate ion homeostasis, positive regulation of catalytic activity, positive regulation of cell population proliferation, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of kinase activity, positive regulation of protein kinase B signaling, positive regulation of proteolysis, protein autophosphorylation, regulation of bile acid biosynthetic process, regulation of extracellular matrix disassembly, regulation of lipid metabolic process, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, heparin binding, transmembrane receptor protein tyrosine kinase activity...
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, heparin binding, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
endoplasmic reticulum, endosome, extracellular region, Golgi apparatus, integral component of plasma membrane, plasma membrane, receptor complex, transport vesicle...
endoplasmic reticulum, endosome, extracellular region, Golgi apparatus, integral component of plasma membrane, plasma membrane, receptor complex, transport vesicle
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fibroblast growth factor receptor 4
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Kaplan plot for FGFR4 in
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*NOTE: the Kaplan plots were collected from OncoLnc