FGFR3
Entrez ID: 2261
Full name: fibroblast growth factor receptor 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: FGFR
Chromosomal location: 4p16.3
Substructure location: Gatekeeper: 555 A-loop: [N/A] G-loop: 478...484 αC-helix: 516...532
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FGFR3
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is r...
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.
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GO - Biological processes (BP):
bone maturation, bone mineralization, bone morphogenesis, cell-cell signaling, chondrocyte differentiation, chondrocyte proliferation, endochondral bone growth, endochondral ossification, fibroblast growth factor receptor apoptotic signaling pathway, fibroblast growth factor receptor signaling pathw...
bone maturation, bone mineralization, bone morphogenesis, cell-cell signaling, chondrocyte differentiation, chondrocyte proliferation, endochondral bone growth, endochondral ossification, fibroblast growth factor receptor apoptotic signaling pathway, fibroblast growth factor receptor signaling pathway, MAPK cascade, multicellular organism development, negative regulation of developmental growth, peptidyl-tyrosine phosphorylation, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of kinase activity, positive regulation of MAPK cascade, positive regulation of phosphatidylinositol 3-kinase activity, positive regulation of phospholipase activity, positive regulation of protein kinase B signaling, positive regulation of tyrosine phosphorylation of STAT protein, protein autophosphorylation, skeletal system development, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, identical protein binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, identical protein binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
endoplasmic reticulum, extracellular region, Golgi apparatus, nucleus, integral component of plasma membrane, plasma membrane, cell surface, receptor complex, transport vesicle...
endoplasmic reticulum, extracellular region, Golgi apparatus, nucleus, integral component of plasma membrane, plasma membrane, cell surface, receptor complex, transport vesicle
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fibroblast growth factor receptor 3
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Kaplan plot for FGFR3 in
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*NOTE: the Kaplan plots were collected from OncoLnc