PRKACB
Entrez ID: 5567
Full name: protein kinase cAMP-activated catalytic subunit beta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: PKA
Chromosomal location: 1p31.1
Substructure location: Gatekeeper: 121 A-loop: 184...204 G-loop: [N/A] αC-helix: [N/A]
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PRKACB
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly an...
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).
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GO - Biological processes (BP):
activation of protein kinase A activity, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, blood coagulation, cellular response to glucagon stimulus, high-density lipoprotein particle assembly, negative regulation of meiotic cell cycle, negative regulation of smoothened sign...
activation of protein kinase A activity, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, blood coagulation, cellular response to glucagon stimulus, high-density lipoprotein particle assembly, negative regulation of meiotic cell cycle, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, neural tube closure, protein kinase A signaling, protein phosphorylation, regulation of protein processing, renal water homeostasis, response to clozapine, signal transduction, stimulatory C-type lectin receptor signaling pathway
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GO - Molecular function (MF):
AMP-activated protein kinase activity, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding, protein kinase A regulatory subunit binding, ubiquitin protein ligase binding...
AMP-activated protein kinase activity, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding, protein kinase A regulatory subunit binding, ubiquitin protein ligase binding
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GO - Cellular component (CC):
centrosome, cytosol, extracellular exosome, intercellular bridge, nucleoplasm, nucleus, plasma membrane, cAMP-dependent protein kinase complex, ciliary base, perinuclear region of cytoplasm...
centrosome, cytosol, extracellular exosome, intercellular bridge, nucleoplasm, nucleus, plasma membrane, cAMP-dependent protein kinase complex, ciliary base, perinuclear region of cytoplasm
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protein kinase cAMP-activated catalytic subunit beta
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*NOTE: the Kaplan plots were collected from OncoLnc