JAK1
Entrez ID: 3716
Full name: Janus kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Jak
Chromosomal location: 1p31.3
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 590...597, 881...887 αC-helix: 629...644, 919...930
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JAK1
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952)....
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).
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GO - Biological processes (BP):
cytokine-mediated signaling pathway, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-2-mediated signaling pathway, inte...
cytokine-mediated signaling pathway, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-35-mediated signaling pathway, interleukin-6-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, intracellular signal transduction, MAPK cascade, positive regulation of homotypic cell-cell adhesion, positive regulation of sprouting angiogenesis, protein localization to cell-cell junction, protein phosphorylation, regulation of interferon-gamma-mediated signaling pathway, response to antibiotic, type I interferon signaling pathway
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GO - Molecular function (MF):
ATP binding, growth hormone receptor binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, protein phosphatase binding, protein tyrosine kinase activity, ubiquitin protein ligase binding...
ATP binding, growth hormone receptor binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, protein phosphatase binding, protein tyrosine kinase activity, ubiquitin protein ligase binding
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GO - Cellular component (CC):
cytoskeleton, cytosol, endosome, nucleus, cytoplasm, focal adhesion, membrane...
cytoskeleton, cytosol, endosome, nucleus, cytoplasm, focal adhesion, membrane
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Janus kinase 1
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Kaplan plot for JAK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc