GUCY2C
Entrez ID: 2984
Full name: guanylate cyclase 2C
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: RGC: RGC
Chromosomal location: 12p12.3
Substructure location: Gatekeeper: 561 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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GUCY2C
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin....
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.
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GO - Biological processes (BP):
cGMP biosynthetic process, digestion, intracellular signal transduction, receptor guanylyl cyclase signaling pathway, regulation of cell population proliferation, response to toxic substance, signal transduction...
cGMP biosynthetic process, digestion, intracellular signal transduction, receptor guanylyl cyclase signaling pathway, regulation of cell population proliferation, response to toxic substance, signal transduction
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GO - Molecular function (MF):
ATP binding, GTP binding, guanylate cyclase activity, natriuretic peptide receptor activity, peptide hormone binding, peptide receptor activity, protein kinase activity, toxic substance binding...
ATP binding, GTP binding, guanylate cyclase activity, natriuretic peptide receptor activity, peptide hormone binding, peptide receptor activity, protein kinase activity, toxic substance binding
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GO - Cellular component (CC):
endoplasmic reticulum membrane, plasma membrane, integral component of membrane...
endoplasmic reticulum membrane, plasma membrane, integral component of membrane
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guanylate cyclase 2C
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A-loop
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αC-helix
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αC-helix
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Kaplan plot for GUCY2C in
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*NOTE: the Kaplan plots were collected from OncoLnc