GRK2
Entrez ID: 156
Full name: G protein-coupled receptor kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: GRK: BARK
Chromosomal location: 11q13.2
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 197...203 αC-helix: 224...229
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GRK2
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPA...
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
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GO - Biological processes (BP):
cardiac muscle contraction, desensitization of G protein-coupled receptor signaling pathway, G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled receptor signaling pathway, heart development, negative regulation of striated muscle contraction, negative regulation of the for...
cardiac muscle contraction, desensitization of G protein-coupled receptor signaling pathway, G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled receptor signaling pathway, heart development, negative regulation of striated muscle contraction, negative regulation of the force of heart contraction by chemical signal, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of catecholamine secretion, receptor internalization, tachykinin receptor signaling pathway, viral entry into host cell, viral genome replication
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GO - Molecular function (MF):
alpha-2A adrenergic receptor binding, ATP binding, beta-adrenergic receptor kinase activity, Edg-2 lysophosphatidic acid receptor binding, G protein-coupled receptor kinase activity, protein kinase activity...
alpha-2A adrenergic receptor binding, ATP binding, beta-adrenergic receptor kinase activity, Edg-2 lysophosphatidic acid receptor binding, G protein-coupled receptor kinase activity, protein kinase activity
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GO - Cellular component (CC):
cytosol, plasma membrane, cilium, cytoplasm, membrane, synapse...
cytosol, plasma membrane, cilium, cytoplasm, membrane, synapse
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G protein-coupled receptor kinase 2
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Kaplan plot for GRK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc