ACVR2A
Entrez ID: 92
Full name: activin A receptor type 2A
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR2
Chromosomal location: 2q22.3-q23.1
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 223...225
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ACVR2A
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin ...
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
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GO - Biological processes (BP):
activin receptor signaling pathway, anterior/posterior pattern specification, BMP signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, determination of left/right symmetry, embryonic skeletal system development, gastrulation with mouth forming second, me...
activin receptor signaling pathway, anterior/posterior pattern specification, BMP signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, determination of left/right symmetry, embryonic skeletal system development, gastrulation with mouth forming second, mesoderm development, penile erection, positive regulation of activin receptor signaling pathway, positive regulation of bone mineralization, positive regulation of erythrocyte differentiation, positive regulation of osteoblast differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of protein phosphorylation, positive regulation of transcription by RNA polymerase II, protein phosphorylation, regulation of nitric-oxide synthase activity, Sertoli cell proliferation, spermatogenesis, sperm ejaculation, transmembrane receptor protein serine/threonine kinase signaling pathway
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GO - Molecular function (MF):
activin binding, ATP binding, BMP receptor activity, coreceptor activity, growth factor binding, inhibin binding, metal ion binding, PDZ domain binding, protein self-association, protein serine/threonine kinase activity, transmembrane receptor protein serine/threonine kinase activity...
activin binding, ATP binding, BMP receptor activity, coreceptor activity, growth factor binding, inhibin binding, metal ion binding, PDZ domain binding, protein self-association, protein serine/threonine kinase activity, transmembrane receptor protein serine/threonine kinase activity
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GO - Cellular component (CC):
activin receptor complex, inhibin-betaglycan-ActRII complex, integral component of plasma membrane, plasma membrane, cell surface, cytoplasm, receptor complex...
activin receptor complex, inhibin-betaglycan-ActRII complex, integral component of plasma membrane, plasma membrane, cell surface, cytoplasm, receptor complex
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activin A receptor type 2A
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Kaplan plot for ACVR2A in
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*NOTE: the Kaplan plots were collected from OncoLnc