KinaseMD - MAPK3

MAPK3 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. View more >>

GO - Biological processes (BP): activation of MAPK activity, activation of MAPKK activity, aging, apoptotic process, arachidonic acid metabolic process, axon guidance, Bergmann glial cell differentiation, BMP signaling pathway, cardiac neural crest cell development involved in heart development, cartilage development, caveolin-mediated endocytosis, cell cycle, cell surface receptor signaling pathway, cellular response to amino acid starvation, cellular response to cadmium ion, cellular response to dopamine, cellular response to mechanical stimulus, cellular response to organic substance, cellular response to reactive oxygen species, cellular response to tumor necrosis factor, decidualization, DNA damage induced protein phosphorylation, ERK1 and ERK2 cascade, face development, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, fibroblast growth factor receptor signaling pathway, interleukin-1-mediated signaling pathway, intracellular signal transduction, lipopolysaccharide-mediated signaling pathway, lung morphogenesis, MAPK cascade, negative regulation of apolipoprotein binding, outer ear morphogenesis, peptidyl-serine phosphorylation, peptidyl-tyrosine autophosphorylation, phosphorylation, platelet activation, positive regulation of cyclase activity, positive regulation of cytokine secretion involved in immune response, positive regulation of ERK1 and ERK2 cascade, positive regulation of gene expression, positive regulation of histone acetylation, positive regulation of histone phosphorylation, positive regulation of macrophage chemotaxis, positive regulation of metallopeptidase activity, positive regulation of protein phosphorylation, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of xenophagy, protein-containing complex assembly, protein phosphorylation, regulation of cellular pH, regulation of cellular response to heat, regulation of cytoskeleton organization, regulation of DNA-binding transcription factor activity, regulation of early endosome to late endosome transport, regulation of gene expression, regulation of Golgi inheritance, regulation of ossification, regulation of phosphatidylinositol 3-kinase signaling, regulation of stress-activated MAPK cascade, response to epidermal growth factor, response to exogenous dsRNA, response to toxic substance, sensory perception of pain, stress-activated MAPK cascade, thymus development, thyroid gland development, trachea formation, transcription initiation from RNA polymerase I promoter, viral process View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

KinaseMD: Kinase mutations and drug responses

MAPK3

Entrez ID: 5595

Full name: mitogen-activated protein kinase 3

External links: HGNC UniprotKB Ensembl RefSeq COSMIC

Family: CMGC: MAPK: ERK1

Chromosomal location: 16p11.2

Substructure location: Gatekeeper: 122 A-loop: 183...209 G-loop: 49...56 αC-helix: 79...94

Data table is loading....

Kaplan plot for MAPK3 in