MARK3
Entrez ID: 4140
Full name: microtubule affinity regulating kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: MARK
Chromosomal location: 14q32.32-q32.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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MARK3
Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of s...
Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
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GO - Biological processes (BP):
intracellular signal transduction, MAPK cascade, microtubule cytoskeleton organization, negative regulation of hippo signaling, peptidyl-serine autophosphorylation, peptidyl-serine phosphorylation, positive regulation of protein binding, protein phosphorylation...
intracellular signal transduction, MAPK cascade, microtubule cytoskeleton organization, negative regulation of hippo signaling, peptidyl-serine autophosphorylation, peptidyl-serine phosphorylation, positive regulation of protein binding, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
ATP binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
cytosol, extracellular exosome, plasma membrane, cytoplasm, dendrite...
cytosol, extracellular exosome, plasma membrane, cytoplasm, dendrite
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microtubule affinity regulating kinase 3
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*NOTE: the Kaplan plots were collected from OncoLnc